Herb: Artichoke, original Author Maria-Teresa Marti

Herb: Artichoke, original Author Maria-Teresa Marti
Herb: Artichoke, original Author Maria-Teresa Marti

http://www.ucdenver.edu/academics/colleges/pharmacy/currentstudents/OnCampusPharmDStudents/ExperientialProgram/Documents/nutr_monographs/Monograph-artichoke.pdf

Health Benefits of Globe Artichokes

Health Benefits of Globe Artichokes朝鮮薊的健康益處

http://www.rjmazza.net.au/index_htm_files/Health%20Benefits.pdf    

Artichokes

Artichokes朝鮮薊
Artichokes朝鮮薊

The Health Benefits of Artichokes, by Dr Wayne Terai

The Health Benefits of Artichokes 朝鮮薊對健康的益處
http://www.burtchchiropractic.com/media/1001_ArtichokesHealthBenefits.pdf

The Health Benefits of Artichokes朝鮮薊對健康的益處

2008 Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress以朝鮮薊萃取物預處理對四氯化碳誘導的肝損傷和氧化應激之效果

·        2008 Güldal Mehmetçik el., Effect of pretreatment with artichoke extract on carbon tetrachloride-induced liver injury and oxidative stress, Volume 60, Issue 6, 18 September 2008, Pages 475–480, Experimental and Toxicologic Pathology (IF: 2.144)

·          2008 以朝鮮薊萃取物預處理對四氯化碳誘導的肝損傷和氧化應激之效果

研究結果表明，在體內以朝鮮薊萃取物給藥可用於對四氯化碳誘導的肝損傷和肝毒性，在預防氧化應激的很有用的。

【說明：以四氯化碳模擬大鼠肝功能所受之化學毒害，而服用朝鮮薊可顯示具有很強大的保護肝臟的作用。】

Artichoke is a plant with antioxidant properties. In this study, we investigated the effect of artichoke extract pretreatment on carbon tetrachloride (CCl₄)-induced oxidative stress and hepatotoxicity. Rats were given artichoke leaf extract (1.5 g/kg/day) by gavage for 2 weeks and after then CCl₄ (1 ml/kg; i.p.) was applied. All rats were killed 24 h after the CCl₄ injection. CCl₄ administration resulted in hepatic necrosis and significant increases in plasma transaminase activities as well as hepatic malondialdehyde (MDA) and diene conjugate (DC) levels in the liver of rats. Glutathione (GSH) and vitamin C levels decreased, but vitamin E levels increased in the liver of CCl₄-treated rats. Hepatic superoxide dismutase (SOD) activities remained unchanged, but glutathione peroxidase (GSH-Px) and glutathione transferase (GST) activities decreased following CCl₄ treatment. In rats pretreated with artichoke extract, significant decreases in plasma transaminase activities and amelioration in histopathological changes in the liver were observed following CCl₄ treatment as compared to CCl₄-treated rats. In addition, hepatic MDA and DC levels decreased, but GSH levels and GSH-Px activities increased without any change in other antioxidant parameters following CCl₄ treatment in artichoke-pretreated rats. The present findings indicate that in vivoarchitoke extract administration may be useful for the prevention of oxidative stress-induced hepatotoxicity.

朝鮮薊是具有抗氧化性質的植物。在這項研究中，我們調查以朝鮮薊提取物預處理對四氯化碳(CCl ₄ ) 誘導的氧化應激和肝毒性的影響。大鼠通過強飼法給予朝鮮薊葉提取物（1.5克/千克/天）2週，在此之後使用注射CCl ₄（1毫升/公斤; IP）。所有大鼠在注入四氯化碳24小時後犧牲。CCl ₄給藥在大鼠的肝臟導致肝壞死和顯著增加血漿轉氨酶(transaminase)的活性以及肝丙二醛（MDA, malondialdehyde）和共軛二烯（DC, diene conjugate）的水平。還原型穀胱甘肽（GSH, Glutathione）和維生素C含量減少，但維生素E含量在CCl ₄處理過的大鼠肝臟有增加。肝超氧化歧化酶（SOD, superoxide dismutase）的活性保持不變，但穀胱甘肽過氧化酶（GSH-PX, glutathione peroxidase）和穀胱甘肽轉移酶（GST, glutathione transferase）活性降低隨著四氯化碳的處理。在大鼠中以朝鮮薊提取物預處理(餵食)，在肝組織病​​理觀察到在相比於四氯化碳處理過的大鼠的變化，血漿中的轉氨酶活性顯著下跌和改善。此外，肝的MDA和DC的水平有所下降，但GSH含量和GSH-Px活性增加，而在其他抗氧化參數沒有任何變化隨著四氯化碳注射在朝鮮薊預處理的大鼠上。本研究結果表明，在體內 Artichoke朝鮮薊提取物給藥可用於預防氧化應激誘導的肝毒性的很有用的。