2014年5月24日 星期六

Artichoke Tea Is Ideal For Your Liver And Heart 朝鮮薊茶非常適合您的肝臟和心臟

Artichoke Tea Is Ideal For Your Liver And Heart
朝鮮薊茶非常適合您的肝臟和心臟
http://www.greenchedy.com/herbal-teas/artichoke-tea-ideal-liver-heart/

January 15, 2013 | By  in HERBAL TEAS
artichoke herb
The Globe Artichoke (Cynara scolymus), is one of the oldest medicinal plants used as a remedy, dating back to 4th century B.C. Ancient Greeks and Romans utilized the artichoke primarily as a digestive aid. In the 16th century, medicinal use of the artichoke was documented for liver problems and jaundice. In 1850, a French physician successfully treated a young boy sick with jaundice for one month using artichoke leaf extract with positive results. This brought attention to artichoke leaf extract as having medicinal value. In Germany, artichoke leaf extract became known in the 17th century, but did not become a popular food item and a promising pharmaceutical plant until the beginning of the 20th century. More recently, artichoke is growing in southern Europe, as well as South America.
Medicinally, the extract is manufactured from the long, deeply serrated basal leaves utilizing highly standardized procedures. The artichoke is a large, thistle-like plant native to the regions of southern Europe, North Africa and the Canary Islands. It is reported that the Globe Artichoke is actually a member of the sunflower family whose use originates in Southern Europe (around the Mediterranean), the flowers of which develop in a large edible bud. The main producers are now France, Italy and Spain where they are eaten in varying ways from deep frying and barbecuing to pizza toppings, but for some reason they have never caught on the UK. The globe artichoke (Cynara cardunculus) is one of the oldest known cultivated vegetables, originating from Ethiopia, with Italy currently being the world’s largest producer. It was valued in ancient Greece and Rome as a digestive aid, available only to the wealthy due to its scarcity. It was the French and Spanish explorers who first brought artichokes to the shores of the United States, and today virtually all of the globe artichokes grown in the US are produced in Castroville, California.

Plant and its ingredients

Artichoke is rich in carbohydrates, antioxidants, vitamins and minerals. The medicinal properties of artichoke come from its cynarin, an active chemical that causes an increased bile flow. The roots and the flower heads may also contain beneficial compounds, however, the leaves contain the higher concentration of these compounds. The leaves of the artichoke contain a high content of pharmacologically active ingredients, including three essential groups consisting of caffeeolyquinic acid (CCS), flavonoids and bitter substances. Within these groups are constituents such as caffeic acid, chlorogenic acid, cynarin (1,5-dicaffeolyquinic acid), luteolin, and the glycosides scolymoside and cynaroside. Among the most important of the CCS are the 1,3-Di-O-CCS, chlorogenic acid and the non-genuine Cynarin, which was the first constituent to be extracted. Cynarin was originally thought to be the single active component in artichoke leaf extract and was often used as a monosubstance. However, further research observes that other active ingredients play a significant role in the effectiveness of artichoke leaf extract antioxidant. It was found that the whole complex of compounds are considered just as active and aid in the many beneficial results.
Artichoke contains bitter principles, cynarin and sesquiterpene-lactones. Scientific studies show that these compounds inhibit cholesterol synthesis and increase its excretion in the bile and thus; have overall cholesterol reduction in the blood. Fresh artichoke is an excellent source of the vitamin folic acid; provide about 68 µg per 100 g (17% of recommended daily allowance). Folic acid acts as a co-factor for enzymes involved in the synthesis of DNA. Scientific studies have proven that adequate levels of folates in the diet during pre-conception period, and during early pregnancy, help prevent neural tube defects in the newborn baby. Fresh globes also contain good amounts of anti-oxidant vitamin; vitamin-C (Provides about 20% of recommended levels per 100 g). Regular consumption of foods rich in vitamin C helps the body develop resistance against infectious agents and scavenge harmful, pro-inflammatory free radicals from the body. It is one of the vegetable sources for vitamin K; provide about 12% of DRI. Vitamin K has potential role bone health by promoting osteotrophic (bone formation) activity. Adequate vitamin-K levels in the diet help limiting neuronal damage in the brain; thus, has established its role in the treatment of patients suffering from Alzheimer’s disease.
Artichoke is also a good source of antioxidants such as silymarin, caffeic acid, and ferulic acid, which help the body protect from harmful free-radical agents. It is also rich in B-complex group of vitamins such as niacin, vitamin B-6 (pyridoxine), thiamin, and pantothenic acid that are essential for optimum cellular metabolic functions. Further, artichoke is rich source of minerals like copper, calcium, potassium, iron, manganese and phosphorus. Potassium is an important component of cell and body fluids that helps controlling heart rate and blood pressure by countering effects of sodium. Manganese is used by the body as a co-factor for the antioxidant enzyme, superoxide dismutase. Copper is required in the production of red blood cells. Iron is required for red blood cell formation. Additionally, it contains small amounts of antioxidant flavonoid compounds like carotene-beta, lutein, and zea-xanthin.

Health Benefits of Artichoke Tea

Artichoke is a powerful player for our health because it is high in fiber and rich in antioxidants. Artichoke can be made into an herbal tea, which affords some of the quality of the whole vegetable. The drink acts as a diuretic and improves liver function. This herbal tea has become more and more favorite around the world thanks to its magnificent health benefits. Although being called tea, this artichoke drink contains no caffeine. Prepared from the roots and flower buds of the artichoke, this herbal tea is tasty, refreshing and nutritious. Drinking artichoke tea regularly is highly recommended to improve the health of tissues. Artichoke tea can help stimulate the immune system, prevent the risk of inflammation and intensify the resistance of the body against illnesses. Now, artichoke tea is not only cleansing and nourishing to the liver and digestive tract, but it can also rid constipation when sipped on daily, can ease IBS symptoms safely, and help keep the hair, nails and skin looking beautiful. The artichoke tea is an infusion of bitter flavor, with diuretics and depurative properties, which contribute to the good hepatobiliary system functioning, to lose weight and to lower the cholesterol, among other benefits for the health.
The Artichoke tea has properties that can help you to reduce the levels of cholesterol, they help to attack the cancer due to the antioxidant capacity that it has. It has also an effect of small weight loss that many people enjoy. Numerous studies have shown that there are many health benefits involving artichoke leaf extracts. Such studies have already proven hepato-protective effects. Artichoke extract has been shown to provide valuable preventative health benefits and protection. In 1997, it was discovered that chlorogenic acid and cynarin were the primary constituents which contributed to the strong antioxidative effect of artichoke leaf extract. These findings documented that artichoke leaf extract prevented oxidative damage to hepatocyte membranes, and suggested that cell protection should not be limited to the hepatocytes. Laboratory investigations are ongoing all over the world regarding the clinical applications of artichoke leaf extract. These investigations include such areas as HIV, cancer and diabetes, and studies so far have been promising. Further investigations continue to find and support the use of artichoke leaf extract as a herbal remedy.
The artichoke tea is rich in folic acid, vitamin A1, vitamin B1, vitamin C as well as in magnesium, phosphorus, calcium, iron, potassium, zinc and dietetic fibers. Artichoke leaf extract has been used as a herbal medicine for many years. Traditional use, as well as recent clinical studies continue to verify the multi-beneficial health benefits of the artichoke leaf extract including lipid-lowering, antioxidant, hepato-protective, choleretic, as well as aiding dyspepsia, and abdominal pain where the stomach, gallbladder, liver and pancreas are primarily affected. Further studies suggest artichoke leaf extract as beneficial in such areas as HIV, cancer, IBS and diabetes. Many constituents of artichoke leaf extract have been identified, and ongoing clinical studies report the medical benefit at different therapeutic levels. The artichoke leaf extract has choleretic, lipid-lowering, antioxidant and hepato-protective effects. It has also been shown to help alleviate abdominal pain. Current research also verifies antiemetic effects of the leaf extract confirming its indication for dyspeptic syndrome. With these clinical and experimental results, it has been determined that artichoke leaf extract is suitable for treating chronic gastrointestinal and specific liver/gallbladder conditions with elevated blood fat values. Artichoke extract is one of the few herbal remedies where the clinical and experimental trials have complemented each other. Both experimental and clinical effects have been verified through extensive biomedical herbal remedy research. Specifically, antioxidant, choleretic, hepatoprotective, bile-enhancing and lipid-lowering effects have been demonstrated, which correspond with its historical use.

Enhances Liver Function and digestion

Artichoke extract has been shown to improve digestion, liver function, and help lower high ldl cholesterol levels and prevent heart disease and artherosclerosis. Artichoke has been shown to be a natural remedy which improves various digestive health disorders, shown to significantly lower blood ldl cholesterol levels, prevent heart disease and atherosclerosis – plaque problems, enhance detoxification reactions, as well as protect the liver from damage. This combination of benefits is very important to healthy liver function. During detoxification of the liver, the toxic substance is often initially converted to an even more toxic form. Without adequate protection, every time the liver neutralizes a toxin, it is damaged in this process. The beneficial health side effects of artichoke leaf extract are due to the promotion of bile flow in the body. The increased bile flow promotes the digestion of fat and contributes to the protection of intestinal mucosa, which is sensitive to acids since the bile fluid contains a considerable amount of bicarbonate. Larger quantities of bile acids entering the duodenum stimulate intestinal peristalsis resulting in better digestion. As the human body consumes toxins in many different forms through food, water, and the air we breathe, these toxins constantly bombard the liver.
Bile serves as a carrier, moving these toxins from the liver on to the intestine for further elimination. When bile excretion is inhibited (cholestasis), these toxins and cholesterol may remain in the liver and have damaging effects. Bile flow inhibition may manifest itself as bile duct obstruction or gallstones. Other reasons that may factor into bile inhibition are excess alcohol ingestion, viral hepatitis, and certain chemicals and drugs. Early stages of liver disease and dysfunction often go undiagnosed because such tests as serum bilirubin, alkaline phosphatase, SGOT, LDH, and GGTP levels remain normal. German researchers confirmed bile promotion by artichoke leaf extract with a double blind clinical study. This study proves that high-dose extracts of artichoke leaves increased bile flow into the duodenum of healthy participants compared to placebo recipients. Bile secretion was measured with special techniques at specific times after participants were given either a single dose of artichoke leaf extract or a placebo. Those who received the artichoke leaf extract showed a significantly higher bile secretion than those who received the placebo. This occurs due to margarine binding with bile salts. Therefore, margarine is not as beneficial in reducing cholesterol as it may seem. It is recommended to drink artichoke tea during the hepatitis treatment period to accelerate the healing of the liver. Artichoke leaf extract protects the liver from the damaging effects of toxins similar to the effect of milk thistle. Like Milk Thistle, artichoke leaf extract stimulates liver tissue regeneration.

For Heart Ailments

It is estimated that in America today, approximately 100 million people have high or borderline high levels of serum LDL cholesterol, with an estimated 1,100,000 new cases of recurrent coronary heart attacks per year. One third of these cases will lead to death. We have foods made with hydrogenated oils, saturated fats, high amounts of processed sugar, and fruits lacking important nutrients. Instead of butter, physicians often recommend margarine which can actually increase blood fat values. Over-consumption of these products contribute greatly to high levels of LDL cholesterol and interfere with cholesterol metabolism. Total cholesterol measurements include LDL (low-density lipoprotein) and HDL (high-density lipoprotein). Oxidized LDL is damaging to the arteries, and causes the formation of atherosclerotic plaques in humans, whereas HDL is beneficial. LDL cholesterol levels should be under 130 mg/dl, HDL cholesterol levels should be above 35 mg/dl with total cholesterol levels under 200 mg/dl according to the American Heart Association. Serum cholesterol levels of 200 mg/dl or above are a major risk factor for Coronary Heart Disease (CHD) which is the single leading cause of death in America today. Two thirds of these 100 million adults also do not receive any form of therapy according to the National Heart, Lung and Blood Institute. There are numerous varieties of cholesterol lowering pharmaceutical drugs available, which are the primary choice of therapy for many adults. Unfortunately, many of these drugs can have very serious side effects prompting further therapeutic treatment. Standardized pharmaceutical grade artichoke leaf extract has been proven as a safe, non-toxic, natural way to prevent and treat high cholesterol.
It accomplishes this in two different ways. Artichoke leaf extract increases the breakdown of cholesterol to bile salts, thus increasing bile production and flow, and regulates the internal production of cholesterol in the liver. In one very interesting study done on rat hepatocytes, a high concentration-dependent inhibition of cholesterol synthesis was found. The 1997 study indicates that artichoke leaf extract reduces the formation of cholesterol and continues to persist for hours after ingestion. This study also indicates that artichoke leaf extract may work through indirect inhibition of the enzyme HMG-CoA reductase similar to “statins” effect. This finding was supported by the fact that artichoke leaf extract blocked insulin-dependent stimulation of HMG-CoA reductase without affecting insulin in general. HMG-CoA reductase is a key enzyme in cholesterol synthesis and generally reduces total cholesterol, LDL cholesterol, and triglyceride levels. Gebhardt’s study also demonstrated that the extract did not interfere with other pathways leading to cholesterol synthesis, which is why adverse effects due to sterol precursor accumulation are not to be expected. In addition to the findings from the animal experiments, numerous studies were also conducted on isolated human hepatocytes. In 1995, Fintelmann published a report on a multicenter structured investigation of 557 patients treated with a special extract from artichoke leaf. Over a period of 43.5 days, the average daily dose given was 1.5 g extract. On an average, serum cholesterol was reduced by 11.5%, and serum triglyceride concentrations decreased 12.5% in patients whose cholesterol values were routinely determined.

For Dyspeptic Syndrome

Another major benefit of artichoke leaf extract is the discovery of its role in dyspeptic syndrome (irritable stomach, nervous gastropathy, meteorism and flatulence, irritable colon functional biliary tract disease). As more and more clinical studies are conducted, the benefits of artichoke leaf extract in the treatment of dyspeptic syndrome confirms its antioxidant health benefits. Artichoke tea may offer relief from common digestive complaints including heartburn, nausea and vomiting. It may also normalize bowel function and relieve constipation, diarrhea and bloating. Artichoke leaves appear to affect the production of bile, which could explain why these related conditions improve. A recent post-marketing surveillance study was conducted with 553 patients over a longer period of time. Notable in this study was that symptoms improved dramatically within 6 weeks of treatment; 98% of these patients believed that artichoke leaf extract was considerably better, somewhat better, or equal to that achieved during previous treatment with other drugs.

Preparation of Artichoke Tea

Making artichoke tea at home is simple, and does not require a lot of time and effort. All you need is some water and a few artichokes to start with. You can make use of any of the three quick and easy methods given below to make this herbal tea at home. Method 1: When cooking artichokes, people often tend to discard its thorny leaves. However, these leaves are in fact full of nutrition. To make use of these discarded leaves, boil 2 cups of water and add 12-15 of them, and let it boil for 5 minutes. Strain the liquid in a cup and drink it twice a day to stay fit and healthy. Method 2: Mash an artichoke and boil it with 2 cups of water for 20 minutes or so. Strain the liquid to separate the remnants, let it cool a bit, and enjoy with a hint of honey in it. This tea has a sweet taste of its own. So adjust the sweetness of the beverage as per choice. Method 3: Separate the leaves, stalk, and roots, and wash them properly. Add about 100 grams of this in 1 liter of water and bring it to a boil. Once it starts boiling, put off the flame and let it stand for 10 minutes. Strain and store the light-green liquid in another container. Drink 2-3 times a day, or as and when required. For those who do not want to take the effort of making tea at home, tea bags of artichokes are available in the market. Tea bags must be dipped in a cup of hot water for about 5 minutes to get the beverage ready to drink. Markets are flooded with several brands of artichoke tea. It is always better to buy one of good quality in order to reap all its benefits.

Side Effects

Artichoke tea and leaf extract are well tolerated and no side effects are known. Artichoke supplementation has been proven to be a safe and natural way to improve and maintain general health due to its many general supportive effects of essential physiological functions. However, before using artichoke tea for cleansing, nourishing and even healing the body it is best to talk to your doctor to make sure it is safe for you to use. It is also wise to keep in mind that there have been allergic reactions to using this herb. Typically, if you are allergic to purple coneflowers and chamomile it is most likely you will be allergic to artichokes as well and it would be wise too not use this as a medicinal tea for the liver and digestive tract. Others who should stay away from this medicinal tea are those suffering from gallstones, kidney disease or are pregnant. Overall, artichokes are safe to use for eating and making medicinal teas when used properly and in moderation. Artichoke leaf extract should not be taken in the presence of gallstones or other bile duct occlusion, due to its bile stimulating effects. Those who are pregnant or nursing a baby should consult their physician before using artichoke leaf extract. Artichoke leaf extract is well tolerated in 95% of cases, with few side effects noted when used in recommended doses. More importantly, numerous studies report absence of adverse side effects using standardized extract compared to placebo. In one large study, 1 in 100 participants reported a transient increase in flatulence. As with other composite flowers (daisies, thistle, Echinacea, chrysanthemums), local a topic reactions have been reported after skin contact with fresh plant or its dried parts. Individuals allergic to dandelion or chamomile have high chances of being allergic to artichoke as well.
- See more at: http://www.greenchedy.com/herbal-teas/artichoke-tea-ideal-liver-heart/#sthash.1EItvOGz.dpuf

Clinical Tested of Herbal Remedies - Artichoke 草藥的臨床測試 - 朝鮮薊

Clinical Tested of Herbal Remedies - Artichoke
草藥的臨床測試 - 朝鮮薊 
http://allergy-book.blogspot.tw/2009/10/clinical-tested-of-herbal-remedies.html

Artichokes were greatly valued by the ancient Greeks (fourth century B.C.) for treating digestive disorders. Clinical studies have been conducted on aqueous extracts of the leaves. The extracts characteristically contain caffeoylquinic acid derivatives, including caffeic acid, chlorogenic acid, and cynarin (1,5-dicaffeoylquinic acid) (Kraft, 1997).
Cynara-SL™ contains 320 mg per capsule of a dried aqueous extract called LI 120, with an herb-to-extract ratio of 3.8 to 5.5:1. It is manufactured in Germany by Lichtwer Pharma AG and distributed in the United States by Lichtwer Pharma U.S., Inc. This extract is marketed in Europe as Hepar-SL forte®.
Valverde Artischocke, which is manufactured by Novartis Consumer Health GmbH in Germany, is not provided in the United States. The tablets contain 450 mg of a dried aqueous extract called CY-450 with a ratio of 25 to 35:1. Artichoke preparations may relieve digestive complaints through increases in the formation and flow of bile.
The increased flow of bile is called choleresis. Bile is excreted from the liver, stored in the gallbladder, and released into the intestine. Bile acids form a complex with dietary fats in the intestine and thereby assist in their digestion and absorption (Kraft, 1997).
In addition, stimulation of bile production results in reduced serum cholesterol, as cholesterol is pulled from the blood to be converted into bile acids. The increased flow of bile may also be beneficial for patients with irritable bowel syndrome (IBS) (Walker, Middleton, and Petrowicz, 2001).
  • Cynara-SL (LI 120) - Choleresis (Bile Secretion)
A mode of action study using the Lichtwer product Cynara-SL (Hepar-SL) demonstrated that artichoke extract increased the flow of bile. Administration of six capsules (1.92 g) intraduodenally caused a peak increase (100 to 150 percent compared to baseline) in bile one hour later (Kirchhoff et al., 1994).
According to Dr. David Heber, this study inferred, but did not clearly demonstrate, therapeutic benefit for dyspepsia; the one-day study was too short, was not conducted on subjects with dyspepsia, and the product was not delivered orally.
  • Valverde Artischocke - Hyperlipoproteinemia (Elevated Cholesterol Levels)
A study with the Novartis product Valverde Artischocke on 131 patients with elevated cholesterol (total serum cholesterol greater than 280 mg/dl) reported a 20.2 percent decrease in cholesterol, compared to 7.2 percent in the placebo group.
The product was given in a dose of 900 mg, twice daily, before meals, for six weeks (Englisch et al., 2000). This well-conducted trial indicates efficacy of Valverde Artischocke in the treatment of elevated cholesterol.
A review of metabolic, pharmacological, and clinical studies described two postmarketing surveillance studies (Kraft, 1997). The first study, reported by Held (1991), included 417 patients with hepatic and biliary tract disease who were treated for four weeks with artichoke leaf extract (product not named).
Prior to the study, the average duration of symptoms of abdominal pain, bloating, meteorism, constipation, lack of appetite, and nausea was four months. Elimination of these symptoms occurred in 65 to 77 percent of patients after one week, and in 52 to 82 percent of patients after four weeks.
The second postmarketing surveillance study was published by Fintelmann (1996) and Fintelmann and Menssen (1996). It included 553 subjects with dyspepsia who were administered the Lichtwer product Hepar-SL. The authors reported a clinically impressive and statistically significant improvement for 87 percent of patients within six weeks of treatment.
In a subset of 302 patients for whom cholesterol values were routinely determined, serum cholesterol and serum triglyceride concentrations dropped significantly (p <>
Walker, Middleton, and Petrowicz (2001) reported an analysis of another patient subset with key symptoms of irritable bowel syndrome (279 in number). These patients experienced significant reductions in symptoms (71 percent) after six weeks of treatment with six capsules per day, with improvement noted within ten days.
Although the initial survey by Fintelmann and Menssen (1996) did not include all the diagnostic criteria for IBS, patients were included if they had at least three of five key symptoms.
No adverse reactions or side effects were reported in the clinical studies described. The Fintelmann (1996) postmarketing study reported that 1.3 percent of 553 subjects experienced mild reactions, such as flatulence, feeling of weakness, and hunger.

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2008 朝鮮薊葉萃取物降低膽固醇

2008 Artichoke Leaf Extract Lowers Cholesterol
 Researchers have found that an over-the-counter Artichoke Leaf Extract (ALE) from the globe artichoke plant can lower cholesterol in otherwise healthy individuals with moderately raised levels. Cardiovascular diseases are the chief causes of death in the UK, and are associated with raised circulating levels of total cholesterol in the plasma.
Once plasma cholesterol reaches a certain level, drugs such as statins are often prescribed to help reduce it. Intervention before concentrations reaches these levels may help reduce the risk of developing cardiovascular diseases without the need for drugs. This new piece of research has shown that otherwise healthy people with moderately raised plasma cholesterol may be able to lower their levels by taking this herbal supplement.
During the trial, 75 volunteers were given 1280mg (4 capsules) of an ALE, or matched placebo, each day for 12 weeks. ALE consumption resulted in a modest but favourable statistically significant reduction in total plasma cholesterol after the intervention period.

朝鮮薊葉萃取物降低膽固醇
研究人員發現,從朝鮮薊植物萃取的非醫師處方朝鮮薊葉萃取物(ALE)可以用於健康人體的適度減緩與降低膽固醇水平。在英國心血管疾病是導致死亡的要成因,並與血漿中總膽固醇增加具循環水平相關聯。
一旦血漿膽固醇達到一定程度,往往建議處方使用如他汀類(Statins)藥物以協助降低它。達到這些濃度水平前而不需要使用藥物的風險,介入治療可能有助於降低罹患心血管疾病。這項新的研究已經表明原本健康的人有溫和升高血漿膽固醇的趨勢,可以通過服用這種草藥作補充劑,以降低他們血漿膽固醇的水平。
在試驗中,75名志願者每一天給予的朝鮮薊萃取物(ALE)1,280mg4粒),或12週相對應的安慰劑。在期間後ALE的使用者產生在統計學優良顯著降低血漿總膽固醇的溫和效果。
【注意:內容以原文為主,譯文僅供參考,有興趣請到原網址查閱與深入了解/CL/

Journal Reference:
Bundy R., et al. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomised double-blind placebo controlled trial. Phytomedicine, DOI:10.1016/j.phymed.2008.03.001


2014年5月23日 星期五

2007 肝纖維化的治療和展望

2007 肝纖維化的治療和展望(華海嬰,郭旭光,楊波) [摘錄]
肝纖維化(Hepaticfibrosis)是指肝細胞發生壞死及炎症刺激時,肝內纖維及成纖維結締組織增生的病理過程,是慢性肝病的重要病理階段,也是發展為肝硬化的物質基礎,並且是個可逆的階段。對此階段的干預治療處於防止肝纖維化向肝硬化轉變的關鍵地位。近年來,關於抗肝纖維化的研究有不少報道,但是臨床上尚無抗肝纖維化的上市特效藥物,且其治療各有所特點,故筆者在此作一綜述以供臨床參考。

...
1.8 二咖啡醯奎尼酸 二咖啡醯奎尼酸是新近我國研發的中藥單體,它能顯著抑制乙肝表面抗原和e抗原的產生以及病毒DNA的複製,且作用持久。且有明顯的抗愛滋病作用。
...

備註:二咖啡醯奎尼酸是由咖啡酸(Caffeic acid)與奎尼酸(Quinic1-羥基六氫沒食子酸)生成的縮酚酸。根據咖啡醯在奎尼酸上的結合部位和數目有不同異構物。

朝鮮薊的生物活性的指標成分就是洋薊素(Cynarine)和綠原酸(Chlorogenic acid,簡稱CA/ChA),均含咖啡酸、多酚、和類黃酮化合物(Flavonoids)。

Cynarine: 就是二咖啡醯奎寧酸,即1,3-Dicaffeoylquinic acid, 1.3-di-O-咖啡醯奎寧酸 (洋薊素)
異構物:
1,5-Dicaffeoylquinic acid

3,5-Dicaffeoylquinic acid(Isochlorogenic acid A, 異綠原酸A)

朝鮮薊研究大事記-2

1996年
德國Fintelmann發表的臨床研究報告,有553名患有消化不良的門診病人,服用朝鮮薊萃取物,經過6個星期的治療,記錄的有效率分別高達:嘔吐(88%)噁心(83%)腹痛(76%)食慾不振(72%)嚴重便秘(71%)脹氣(68%)肥胖(59%)


1996年
德國Herbalgram,在臨床試驗中選擇患有急、慢性代謝紊亂(IBS)的20名男性患者進行試驗,經由測量十二指腸內膽分泌特性來評估朝鮮薊對肝臟的效果,服用30分鐘後,膽汁分泌增加了127.3%;60分鐘後增加了151.5%, 120分鐘後增加了94.3%,其利膽作用及其藥物研究,對治療和預防肝膽疾病及其引發的相關病症,具有重要的意義。


1999年
英國GUY醫院提出【朝鮮薊萃取物抗動脈粥樣硬化】的有效作用。


2001年
德國發表的研究報告證實朝鮮薊有效治療高脂血症、預防動脈硬化、冠心病和保護心臟的作用。研究還表明,膽汁分泌和排出量的增加,在從人體排泄過多膽固醇過程中膽汁有著關鍵作用。


2002年9月


英國【朝鮮薊對實驗鼠利膽作用和促進脂質排泄作用研究】
結論:朝鮮薊不僅有利膽作用,而且還能分解排出過多的脂肪和膽固醇。

朝鮮薊研究大事記-1

16世紀
有朝鮮薊作為藥物用於治於治療黃疸、肝臟問題的使用記載。


1850年
一名法國醫生用朝鮮薊萃取物,在一個月成功治療一名患有黃疸的男童。


1930年
臨床研究朝鮮薊萃取物對肝臟保護作用的成績令人鼓舞。


1934年
在朝鮮薊中發現洋薊酸cynarin成分及其強大的抗氧化、防衰老作用。


1940年
日本研究指出,朝鮮薊萃取物不僅可以降低膽固醇,而且還能促進肝臟功能和膽汁分泌,有助於消化和排泄。


1966年~ 1968年
研究指出,以朝鮮薊萃取物對老鼠的肝臟切除一部分後的再生效應研究。觀察肝組織和肝細胞RNA的含量有明顯的再生增加,刺激細胞分裂及肝細胞膜脂質修復功效,增加肝臟血液循環。


1978年
研究專員Wojiciki在一項研究中用朝鮮薊萃取物治療酒精中毒老鼠,結果大幅減少酒精中毒大鼠的症狀,並發現血清膽固醇和肝臟中的也降低。


1995年
德國Fintelmann的臨床研究報告,讓557名患有心腦血管代謝問題患者服用朝鮮薊萃取物。經過43.5天的測定記錄分析,平均膽固醇下降了11.5%,三酸甘油酯含量下降12.5%。

2013 芹菜,朝鮮薊含有類黃酮化合物能殺死人胰腺癌細胞

Celery, artichokes contain flavonoids that kill human pancreatic cancer cells
PUBLISHED AUGUST 15, 2013
芹菜,朝鮮薊含有類黃酮化合物能殺死人胰腺癌細胞
2013815日出版


URBANA ,伊利諾州 - ​​芹菜,朝鮮薊(Artichoke)和草藥,尤其是墨西哥牛至,都含有芹菜素(Apigenin)和木犀草素(Luteolin),根據伊利諾伊州州大學的兩個新研究的,在實驗室中類黃酮(Flavonoids)通過抑制一種重要的酶能殺死人胰腺癌細胞(Human Pancreatic Cancer)

 “單獨芹菜素誘導使積極侵略兩種人類胰腺癌細胞株的細胞死亡。但是我們得到最好的結果,當我們預先24小時處理的芹菜素與癌細胞,再使用化療的藥物吉西他濱(Gemcitabine)36小時。埃爾維拉德梅西亞教授(Prof. Elvira de Mejia)說,食品化學和食品毒理學系,伊利諾大學。

訣竅似乎是使用類黃酮作為前處理,而不是同時給與這些化療藥物,茱蒂約翰遜(Jodee Johnson) 說,在德西亞實驗室已經畢業的博士生。
儘管話題仍有爭議,我們的研究表明,在同一天服用抗氧化補充劑,化療藥物可能會抵消這些藥物的效果。她說。

這是因為類黃酮可以作為抗氧化劑。一般化療藥物殺死細胞的方式是根據自己的親氧化活性,這意味著類黃酮化合物和化療藥物可當作為他們同時在相互競爭。她解釋說。

胰腺癌是一種非常具侵略破壞性的嚴重癌症,並且很少有早期症狀的,這意味著通常沒有發現它之前疾病已經擴散。最終的​​目標是開發一個治愈方式,但延長患者的生命將會是一個明顯的發展方向,約翰遜補充說。
它是相關癌症中的第四大死亡原因,且五年的存活率只有6%,她說。

科學家們發現,芹菜素可以抑制稱為糖原合成酶激酶-3β Glycogen synthase kinase-3β, GSK-3β )的酶,在導致減少胰腺癌細胞所產生的抗凋亡基因。細胞凋亡是指癌細胞自我毀滅,是因為它的DNA已經被破壞。

在一個癌細胞株申,細胞發生凋亡的比例從沒有被類黃酮處理的8.4 %上升到在已被50微摩爾劑量處理過的細胞達43.8 %。在這種情況下,沒有化療藥物已被添加。

以類黃酮治療還可修正基因的表現。某些基因與促炎性細胞因子具高度的上調關聯。·梅西亞說。

據約翰遜稱,科學家們在體外研究中分子營養與食品研究(Molecular Nutrition and Food Research )首次表明,芹菜素治療可導致胰腺細胞增加白細胞介素-17s ,顯示出其在抗胰腺癌活性潛在的相關性。

胰腺癌患者很可能無法攝入足夠的富含類黃酮的食物,以提高黃酮類化合物在血漿水平的有效程度。但是,科學家們可以設計藥物,以實現這些濃度,德·梅希亞說。

和預防這種可怕的疾病​​則是另一回事。在你的一生中如果你吃了很多的水果和蔬菜,你將可長期接觸這些具生物活性的類黃酮,這無疑將有助於減少患癌症的風險。她說。

類黃酮芹菜素修飾的基因並表現在炎症和癌症與通過抑制GSK-3β/NF-κB信號級聯誘導人胰腺癌細胞凋亡的關聯 可預先在網上公佈分子營養與食品。


資料來源:

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2012 Breast Cancer朝鮮薊誘導凋亡和減少人類乳癌研究

J Cell Physiol. 2012 Sep;227(9):3301-9. doi: 10.1002/jcp.24029.
Original Research Article:
Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231
  1. Anna Maria Mileo1,
  2. Donato Di Venere2,
  3. Vito Linsalata2,
  4. Rocco Fraioli3,
  5. Stefania Miccadei4,*
Article first published online: 17 MAY 2012
DOI: 10.1002/jcp.24029
Abstract
The human breast cancer cell line, estrogen receptor negative, MDA-MB231, was used to evaluate the antitumor effect of polyphenolic extracts from the edible part of artichokes (AE s). Treatment of cancer cells reduced cell viability and inhibited cell growth in a dose-dependent manner. Importantly, AEs did not have any effect on normal breast epithelial cell line, MCF10A. Chlorogenic acid (ChA), the most representative component of the polyphenolic fraction of artichoke, had no prominent effects on the cell death rate of MDA-MB231 cells. The addition of AEs to the cells, rather than ChA, triggered apoptosis via a mitochondrial and a death-receptor pathway, as shown by the activation of caspase-9 and caspase-8, respectively. Furthermore, an increase of the Bax:Bcl2 ratio and up-regulation of cyclin-dependent kinase inhibitor, p21WAF1, crucial apoptotic players, were documented. According to our data on activation of caspase-9, a loss of mitochondrial transmembrane potential (Ψm) was shown. Cell motility and invasion capabilities were remarkably inhibited by AEs-treatment in highly invasive MDA-MB231 cells. In addition, a significant decrease of proteolytic activity of metalloproteinase-2 protein (MMP-2), involved in degrading components of the extracellular matrix, was detected. Our findings indicate that AEs reduced cell viability, inhibited cell growth, triggered apoptotic mechanisms, and showed inhibitory properties against the invasive behavior of MDA-MB231 cancer cell line. Altogether, these data indicate the potential chemopreventive activity of artichoke polyphenolic extracts. J. Cell. Physiol. 227: 3301–3309, 2012. © 2011 Wiley Periodicals, Inc.



朝鮮薊多酚誘導細胞凋亡和降低人類乳腺癌細胞株MDA-MB231的侵襲潛力
摘要
人類乳腺癌細胞株雌激素受體陰性,MDA-MB231,是用來評估的朝鮮薊可食部分(AES)的多酚提取物的抗腫瘤作用。癌細胞的治療是降低細胞活力和劑量依賴型抑制細胞生長。重要的是,AES不會影響任何正常乳腺上皮細胞系,MCF10A。綠原酸(CHA),朝鮮薊的多酚成份中最具代表性含量的一種,MDA-MB231細胞的細胞死亡率無顯著影響。當AES加入到該細胞中,而不是CHA,除了通過線粒體和死亡受體途徑引發細胞凋亡,如所示之分別活化caspase-9caspase-8。此外,增加的Bax:Bcl2的比例和上調細胞週期蛋白依賴性激酶抑製劑,p21WAF1,被記錄為重要的細胞凋亡之成員。根據我們的數據在激活的caspase-9,結果表明線粒體跨膜電位(Ψm)的損失。由AES-治療高度侵襲MDA-MB231細胞的細胞運動和侵襲能力被明顯受到抑制。此外,一個顯著減少金屬蛋白酶2蛋白(MMP-2)的水解活性被檢測出,一種參與細胞外基質的降解成分。我們的研究結果表明,AES降低細胞活力,抑制細胞生長,引發細胞凋亡機制,並展示對入侵行為的MDA-MB231癌細胞株的抑制性能。總之,這些數據表明,朝鮮薊多酚提取物在化學預防活動的潛力。細胞研究。生理學。 2273301-33092012 ©2011威利公司
【注意:內容以原文為主,譯文僅供參考,有興趣請到原網址查閱與深入了解/CL/