Effects of Artichoke
Extract Supplementation on Gonads of Cadmium-Treated Rats
Abstract
The present study
was designed to determine whether artichoke (Cynara scolymus) exerts a protective
effect on gonads of cadmium-treated rats and if there is a relationship between
artichoke supplementation and nitric oxide (NO) formation in cells. Forty
Wistar albino male rats, weighing an average of 90 g each, were equally divided
into four groups receiving 1 mg/100 g cadmium chloride by injection
(group 1), the same dose CdCl2 plus
3 mg/100 g artichoke extract (group 2), the same dose of artichoke
extract (group 3), and male controls (group 4). Four additional groups, labeled
5–8, consisted of identically treated and control female rats. After
4 weeks of treatment, the animals were killed and their gonads were
removed for histological examination. As expected, the seminiferous tubules and
Leydig cells were damaged by cadmium. Ovarian tissue was not damaged to the
same extent as testicular cells. Artichoke extract exerted a clear protective
effect against Cd-induced testicular damage and lowered NO production to the
same level of that in the control groups.
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朝鮮薊提取物補充劑對鎘處理大鼠性腺的影響
摘要
本研究的目的是確定朝鮮薊（Cynara scolymus）以大鼠施加鎘處理對性腺有保護作用，在於有朝鮮薊作補充品和細胞中的一氧化氮（NO）生成的關係。40只Wistar白化雄性大鼠，體重平均為每一隻90g，隨機分為4組，分別接受注射1mg/100g氯化鎘（第1組），相同劑量的氯化鎘(CdCl2)再加3mg/100g朝鮮薊提取物（組2），相同劑量的朝鮮薊提取物（第3組），和男性對照組（第4組）。另外四個組，標記為5-8，為雌性大鼠以完全一樣的對待和控制。治療4週後，犧牲動物，取出性腺組織進行實檢查。正如所料，輸精管(Seminiferous tubules)和間質細胞(Leydig cells)被鎘破壞。卵巢組織(Ovarian tissue)不被破壞的程度如同睾丸細胞(Testicular cells)。朝鮮薊提取物顯明的對施加鎘誘導的睾丸損害具保護作用和降低相同對照組的NO產生。
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